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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF4
All Species:
30.61
Human Site:
Y443
Identified Species:
44.89
UniProt:
O43172
Number Species:
15
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O43172
NP_004688.2
522
58449
Y443
L
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
Chimpanzee
Pan troglodytes
XP_520198
559
62217
Y480
L
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
Rhesus Macaque
Macaca mulatta
XP_001102859
521
58408
Y442
L
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
Dog
Lupus familis
XP_532038
521
58332
Y442
L
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9DAW6
521
58352
Y442
L
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
Rat
Rattus norvegicus
Q5BK30
415
45841
C337
Y
N
A
T
T
R
K
C
I
T
K
L
E
G
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001518220
390
43930
T312
R
Q
R
R
C
V
Y
T
I
P
A
H
Q
N
L
Chicken
Gallus gallus
Q5ZMA2
505
55116
N427
W
D
L
R
K
L
K
N
F
K
T
L
Q
L
D
Frog
Xenopus laevis
Q5FWQ6
415
45899
C337
Y
S
A
S
S
R
K
C
L
A
K
L
E
G
H
Zebra Danio
Brachydanio rerio
Q1LV15
415
45916
C337
F
S
T
D
T
F
Q
C
L
C
Q
L
E
G
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KNS3
411
46441
L332
D
V
S
V
G
L
C
L
L
T
L
S
G
H
D
Honey Bee
Apis mellifera
XP_393186
525
59172
Y444
L
R
K
R
S
C
V
Y
T
I
P
A
H
T
N
Nematode Worm
Caenorhab. elegans
Q10051
492
53189
N414
W
D
L
R
K
L
K
N
L
K
T
F
A
N
E
Sea Urchin
Strong. purpuratus
XP_795434
502
56264
Y423
M
R
Q
R
K
V
L
Y
T
I
P
A
H
Q
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O22212
554
61823
Y459
L
R
M
R
K
S
L
Y
I
I
P
A
H
A
N
Baker's Yeast
Sacchar. cerevisiae
P20053
465
52424
N387
K
R
D
E
G
Q
L
N
Q
I
L
A
H
R
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
92.8
99
99.2
N.A.
98.8
25.4
N.A.
71.2
21
24.1
24.3
N.A.
22.2
58.2
22
62
Protein Similarity:
100
93.1
99.2
99.6
N.A.
99.4
40.6
N.A.
73.3
41.3
41.3
41.5
N.A.
39.6
72.9
40.6
77
P-Site Identity:
100
100
100
100
N.A.
100
0
N.A.
6.6
6.6
0
0
N.A.
0
80
6.6
73.3
P-Site Similarity:
100
100
100
100
N.A.
100
6.6
N.A.
20
20
6.6
6.6
N.A.
13.3
86.6
13.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
40
31.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
55.7
51.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
60
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
13
0
0
0
0
0
0
7
7
57
7
7
0
% A
% Cys:
0
0
0
0
7
38
7
19
0
7
0
0
0
0
0
% C
% Asp:
7
13
7
7
0
0
0
0
0
0
0
0
0
0
13
% D
% Glu:
0
0
0
7
0
0
0
0
0
0
0
0
19
0
7
% E
% Phe:
7
0
0
0
0
7
0
0
7
0
0
7
0
0
0
% F
% Gly:
0
0
0
0
13
0
0
0
0
0
0
0
7
19
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
7
57
7
19
% H
% Ile:
0
0
0
0
0
0
0
0
19
57
0
0
0
0
0
% I
% Lys:
7
0
7
0
25
0
25
0
0
13
13
0
0
0
0
% K
% Leu:
44
0
13
0
0
19
19
7
25
0
13
25
0
7
7
% L
% Met:
7
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
7
0
0
0
0
0
19
0
0
0
0
0
13
57
% N
% Pro:
0
0
0
0
0
0
0
0
0
7
50
0
0
0
0
% P
% Gln:
0
7
38
0
0
7
7
0
7
0
7
0
13
38
0
% Q
% Arg:
7
57
7
69
32
13
0
0
0
0
0
0
0
7
0
% R
% Ser:
0
13
7
7
13
7
0
0
0
0
0
7
0
0
0
% S
% Thr:
0
0
7
7
13
0
0
7
44
13
13
0
0
7
0
% T
% Val:
0
7
0
7
0
13
38
0
0
0
0
0
0
0
0
% V
% Trp:
13
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
13
0
0
0
0
0
7
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _